Active substances: Azithromycin
All adverse events, including hearing impairment, cardiac dysrhythmias, prolonged QT interval on ECG, and hepatotoxicity. Azithromycin is not approved for preventing bronchiolitis obliterans syndrome.
It is an FDA-approved antibiotic used to treat many types of infections affecting the lungs, sinuses, skin, and other parts of the body. The drug has been used for more than 26 years.
It is sold under the brand names Zithromax and Zmax and as generics by many different drug companies. Are reports of the study free of suggestion of selective outcome reporting reporting bias?
Was the study apparently free of other problems that could put it at a risk of bias?
Where continuous scales of measurement are used to assess the effects of treatment FEV 1, the mean difference MD will be used, or the standardised mean difference SMD if different scales have been used. If standard deviations of changes from baseline such as for FEV 1 are missing, these will be calculated if other information such as P values are available.
If this is not possible, we will impute standard deviations using the methods from the Cochrane Handbook Chapter 16. Assessment of heterogeneity We will first assess the heterogeneity by visual inspection of the forest plot.
The importance of the observed value of I 2 depends on the magnitude and direction of treatment effects and the strength of evidence for heterogeneity e.
Assessment of reporting biases If possible, funnel plots will be used to assess for the potential existence of publication bias Higgins. Sign in or purchase a subscription to access this content.
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