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You mean the prospect for peace seems so remote. Newer generation macrolides, such as azithromycin and clarithromycin, are characterized by fewer side-effects and increased anti-inflammatory properties when compared to erythromycin.
Additionally, azithromycin has increased antimicrobial activity against Ureaplasma urealyticum when compared to erythromycin.
The inflammatory nature of BPD is clearly established, but a safe and affordable therapy that will decrease its severity and incidence is lacking. Azithromycin, a macrolide antibiotic, has potent anti-inflammatory properties and an excellent side effect profile, but it has not been studied in premature infants.
We performed a pilot study to evaluate the efficacy and safety of azithromycin in the prevention of BPD.
Our hypothesis is that prophylaxis with azithromycin is both safe and effective at reducing the incidence and severity of BPD in the extremely preterm infant. Methods The pilot study was double blinded, placebo controlled, randomized, and approved by the Institutional Review Board at the University of Kentucky.
Informed consent was obtained when the infant met enrollment criteria.View All Indications and Usage for drug-resistant bacteria and maintain the effectiveness drug indicated for the treatment of patients with mild to moderate infections treat infections that are proven or designated microorganisms in the specific conditions listed below.
Exclusion criteria included lack of parental informed consent, confirmed sepsis by blood culture drawn at admission, multiple congenital anomalies or known syndromes, and intrauterine growth retardation with birth weight less than tenth percentile for gestational age.
Infants who did not receive mechanical ventilation were not eligible for the study.