Active substances: Norfloxacin
Therapy with rifampicin or ursodeoxycholic acid UDCA was also available throughout the study if needed. Nineteen individuals, aged between 1 and 17 years, were enrolled reporting itching by a visual itch score using patient data.
Results showed that pruritus improved in 14 of 19 cases and the mean level of serum bile acid was reduced. Seven out of nine individuals displayed considerable reductions in serum bile acid.
There were no serious side effects of the drug, and few mild side effects could be related directly to the drug. Currently, there are few therapeutic options with limited efficacy, so new treatment strategies for pruritus are of great importance for clinical practice.
Inhibition of intestinal bile acid absorption improves chloestatic liver and bile duct injury in a mouse of sclerosing cholangitis. J Hepatol. Scoring ranges from A—C, with the most advanced cases falling within the C category.
Decompensation of the liver, whereby the functioning of the liver is hindered due to extensive scarring, is seen in patients with Child—Pugh class C cirrhosis.
On completion of the 6-month treatment phase, it was noted that fewer patients had died in the norfloxacin subgroup compared to placebo 22 [15.
Patient follow-up was performed for an additional 6 months, subsequent to the 6-month treatment phase, to monitor infection, death, and additional liver-related complications.
Cumulative mortality incidence was lower in the active norfloxacin subgroup than the placebo group 15. However, at 12-month follow-up the cumulative incidence of death was comparable across the two groups.
Cognitive Impairment Improved by Faecal Microbiota FAECAL transplantation of bacteria given from healthy individuals to those suffering from hepatic encephalopathy has been shown to improve cognitive function.
A significant decline in hospitalisation for recurrent encephalopathy was reported. The treatment was well- tolerated with no serious side effects. Faecal transplantation is an innovative and promising approach to treat this condition, and we look forward to more studies being conducted to confirm our results.
They were followed-up 150 days after they received treatment. In addition, only 1 patient from the faecal transplant group demonstrated a decline in cognitive function, yet following the faecal transplantation returned to baseline.
Researchers examined which metabolic factors best predicted severe liver diseases whilst classifying the results based on the amount of alcohol consumed reported in the Finnish Health Study, a nationally representative cohort.
A total of 6,732 individuals were included, all without known liver disease. The research collected follow-up data over the next decade of liver-related cancer, hospital admissions, and deaths.
NAFLD is an accumulation of fat within the liver, which can ultimately result in cirrhosis, an increased risk of cancer, cardiovascular disease, and kidney malfunction.