Active substances: Norfloxacin
Call your doctor for medical advice about side effects.
What other drugs will affect ofloxacin? Some medicines can make ofloxacin much less effective when taken at the same time. If you take any of the following medicines, take your ofloxacin dose 2 hours before or 2 hours after you take the other medicine.
This list is not complete. Not all possible drug interactions are listed here.
Where can I get more information? Your pharmacist can provide more information about ofloxacin.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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Bacterial translocation BT and migration of viable microorganisms from the intestinal lumen to the mesenteric lymph nodes and other extraintestinal sites have been postulated as the main mechanism in the pathogenesis of SBP.
Translocation of the enteric organisms to mesenteric lymph nodes is increased in patients with advanced cirrhosis and is reduced by selective intestinal decontamination.
Alternative antibiotics include ciprofloxacin 750 mg once weekly, orally or cotrimoxazole 800 mg sulfamethoxazole and 160 mg trimethoprim daily, orally.
Sparfloxacin is a broad spectrum antibiotic, active against varieties of bacteria that are considered predisposing agents for SBP such as E. In addition, it belongs to third generation fluoroquinolones FQs which have better activity against Gram-positive Cocci and anaerobes in comparison with ciprofloxacin.
The difference in spectrum of activity is largely caused by increased activity against the DNA-gyrase of Gram-positive bacteria, rather than activity against Topoisomerase IV, which is the target in Gram-positive bacteria for the older quinolones.
Pentoxifylline prevents bacterial translocation after intestinal obstruction in an experimental model as ischemic injury of intestinal mucosa plays a role in pathogenesis of bacterial translocation.
In cirrhotic rats with ascites, pentoxifylline as well as norfloxacin reduces intestinal bacterial overgrowth, bacterial translocation, and spontaneous bacterial peritonitis.