Active substances: Norfloxacin
At the respective doses, mean peak serum and plasma concentrations of 0. The effective half-life of norfloxacin in serum and plasma is 3—4 hours.
Steady-state concentrations of norfloxacin will be attained within two days of dosing. Norfloxacin is least soluble at urinary pH of 7.
Other companies initiated fluoroquinolone discovery programs in the aftermath of the publication of the norfloxacin patent. Bayer Pharmaceuticals discovered that the addition of a single carbon atom to the norfloxacin structure provided another 4 to 10-fold improvement in activity.
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Take norfloxacin exactly as your doctor tells you to. The usual dose is one 400 mg tablet, taken twice a day. Swallow the tablet with a drink of water. This is because your body absorbs less norfloxacin after a meal, which means the medicine is less effective.
Try to space out the doses over the day - so ideally, take a dose every 12 hours. Do not drink milk or take indigestion remedies or medicines containing iron or zinc such as multivitamin tablets during the two hours before you take norfloxacin, or during the two hours after you have taken a dose.
This is because these things interfere with the way norfloxacin is absorbed by your body, and stop it from working fully. If you forget to take a dose, take it as soon as you remember unless your next dose is due. If your next dose is due then take the dose which is due but leave out the forgotten one.
Do not take two tablets together to make up for a missed dose.
Even if you feel your infection has cleared up, keep taking the antibiotic until the course is finished unless you are told to stop by your doctor.
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