Active substances: Norfloxacin
If you have any problems with the way your kidneys work. Note: "Outline" version has more questions? During the 1980 s, fluorinated derivatives of related quinolones were introduced.
These fluoroquinolones are useful for treating infections caused by some gram positive organisms as well as the expected gram negative organisms and possess pharmacokinetic characteristics that render them suitable for treating systemic infections.
Enrofloxacin ] is a derivative produced exclusively for veterinary applications. Norfloxacin ] and ciprofloxacin ] are derivatives that have been approved for human applications.
Structure and Chemical Characteristics The quinolones are carboxylic acids and contain a quinolone ring. Systemically effective, broad spectrum quinolones possess a fluoro group on the main ring.
The fluoroquinolones also contain protonatable nitrogens and, therefore, can exist as zwitterions. Simple predictions about effect of pH on ion trapping cannot be made.
The activity of the quinolones is reduced by acidic pH, urine! The piperazinyl group confers activity against some Pseudomonas spp. Mechanism of Action Manufacturers of fluoroquinolones emphasize the fact that these drugs have very different mechanisms of action from such groups as the beta-lactams and aminoglycosides.
Rodrigues, Henrique A. Almeida, and Edmundo Gomes de Azevedo. Maddileti. Jayabun, and Ashwini Nangia.
Sandipan Roy and Kumar Biradha.
Molecular Pharmaceutics . What should I avoid while taking norfloxacin? Avoid taking the following medicines within 2 hours before or after you take norfloxacin.
These other medicines can make norfloxacin much less effective when taken at the same time: antacids that contain magnesium or aluminum such as Maalox, Mylanta, or Rolaids, or the ulcer medicine sucralfate Carafate; didanosine Videx powder or chewable tablets; vitamin or mineral supplements that contain iron or zinc.
Do not take norfloxacin with dairy products such as milk or yogurt.
They could make the medication less effective. Avoid caffeine while you are taking norfloxacin, because the medication can make the effects of caffeine stronger. Avoid exposure to sunlight or tanning beds.