Active substances: Norfloxacin
Contraindications As noted above, under licensed use, norfloxacin is also now considered to be contraindicated for the treatment of certain sexually transmitted diseases by some experts due to bacterial resistance.
Patients taking any of these drugs concomitantly with norfloxacin should be carefully monitored.
Pregnancy Norfloxacin has been reported to rapidly cross the blood-placenta and blood-milk barrier, and is extensively distributed into the fetal tissues.
For this reason norfloxacin and other fluoroquinolones are contraindicated during pregnancy due to the risk of spontaneous abortions and birth defects. The manufacturer only recommends use of norfloxacin during pregnancy when benefit outweighs risk.
Ciprofloxacin is being licensed for the treatment of Complicated Urinary Tract Infections and Pyelonephritis due to Escherichia coli and Inhalational Anthrax post-exposure and levofloxacin was recently licensed for the treatment of Inhalational Anthrax post-exposure.
However, the Fluoroquinolones are licensed to treat lower respiratory infections in children with cystic fibrosis in the UK.
Adverse effects In general, fluoroquinolones are well tolerated, with most side-effects being mild to moderate. Both David and I order samsa — a pasty-like snack which traditionally is made from a choice of meat, spinach or pumpkin.
Today we have the meat variety.
Desert Drive Driving out of town we head for the Karakum Desert and the adventure that lured me to this country in the first place. I love these little three wheel tractors - I have never seen those anywhere else There are miles and miles of cotton fields along the side of the road After a couple of hours, we leave the sealed road behind and continue on sandy tracks.
I have to pinch myself at this stage, as it doesn't seem real. For so many years I have dreamed about the burning crater of Darwaza, expecting it to be out of reach for me, and here I am, on my way to see it, and in a few hours I shall be feeling its heat.
I gasp as we reach the top of a hill, and there, spread below me, is the flat desert floor. With a huge hole.