Active substances: Norfloxacin
Molina, Prof. Robert Grubbs, Prof.
Richard R. Ernst, Prof.
Several flavanoids and flavonoids studied by us exhibited a broad antipicornavirus spectrum. Methods: In preliminary studies, the cytotoxicity of all the compounds was evaluated by measuring the effect on morphology, viability and growth of HeLa Ohio cells.
The inhibitory activity on HRV 1 B and 14 replication was evaluated in a plaque reduction assay, starting from the maximum non-cytotoxic concentration MNTC.
Group B contains twice as many serotypes as group A, and accounts for five times as many colds as serotypes group A. The low cytotoxicities resulted in high therapeutic indexes for all these compounds.
Moreover, the decreased susceptibility of the virus to inactivation by mild acid pH or heat, suggest a stabilizing action of 2 b on virion capside conformation. The therapeutic spectrum of cisplatin is limited, however, as frequent types of cancer are resistant to the drug or become resistant during therapy.
Many patients undergo cycles of partial disease remission, resistance, relapse, and treatment with another drug, until further therapy is considered ineffective. Therefore, the search for new anticancer drugs has continued and extended to compounds of non-platinum metals, most notably ruthenium and rhodium.
The importance of high-level computation in these research efforts is rapidly increasing.
Methods: Platinum, ruthenium, and rhodium anticancer agents and their reactions with small models of biomolecules were investigated using computational methods, including quantum chemistry and statistical mechanics for calculating free energies of isolated molecules as well as continuum dielectric methods for calculating energy changes arising from the biological environment.
Results: 1. The computations predict the reactivity of platinum anticancer drugs such as cisplatin towards various functional groups of biomolecules and help identify active drug metabolites.
The complicated molecular mechanism of the binding of the anticancer compound dirhodium tetraacetate to the nucleobases guanine and adenine has been clarified by computation.
The mechanism was elusive despite many experimental studies.
Conclusions: High-level computations are complementary to experimental work; they provide promising tools for future guidance of experiments in the development of novel metallo-drugs. Transplant recipients require life long immunosuppression to prevent allograft rejection placing them at risk of opportunistic infections.
We report a single centre experience of treating fungal infections with the newer antifungal agents. Patients requiring inpatient treatment of fungal infections were identified from pharmacy records.
Diagnosis required a clinically compatible illness with either the fungus identified in bronchoalveolar lavage specimens, blood or biopsy by microscopy or culture, or radiological evidence of compatible pulmonary lesions after excluding other aetiologies.
Outcomes are reported as either successful Complete Response: Resolution in clinical signs and symptoms with regression of radiological lesions. Partial Response: Clinical improvement with marked improvement in radiological lesions.