Active substances: Norfloxacin
Medical uses The initial approval by the U.
As such, these drug interactions involving the fluoroquinolones appear to be drug specific rather than a class effect. The fluoroquinolones have also been shown to interfere with the metabolism of caffeine and the absorption of levothyroxine.
This might increase the risk of methotrexate toxic reactions. Current or past treatment with oral corticosteroids is associated with an increased risk of Achilles tendon rupture, especially in elderly patients who are also taking the fluoroquinolones.
Careful monitoring and supportive treatment, monitoring of renal and liver function, and maintaining adequate hydration is recommended by the manufacturer.
At the respective doses, mean peak serum and plasma concentrations of 0.
The effective half-life of norfloxacin in serum and plasma is 3—4 hours. Do not drink milk or take indigestion remedies or medicines containing iron or zinc such as multivitamin tablets during the two hours before you take norfloxacin, or during the two hours after you have taken a dose.
This is because these things interfere with the way norfloxacin is absorbed by your body, and stop it from working fully. If you forget to take a dose, take it as soon as you remember unless your next dose is due.
If your next dose is due then take the dose which is due but leave out the forgotten one.
Do not take two tablets together to make up for a missed dose. Even if you feel your infection has cleared up, keep taking the antibiotic until the course is finished unless you are told to stop by your doctor.
This is to prevent the infection from coming back. If you have a long-term chronic infection, your course of treatment will be for longer than this, possibly for 1-3 months.
If you still feel unwell after finishing the course of tablets, go back to see your doctor. Getting the most from your treatment Remember to keep any routine appointments with your doctor.
This is so your progress can be monitored. Feeling sick nausea or being sick vomiting, indigestion, tummy abdominal pain Stick to simple foods - avoid rich or spicy meals Diarrhoea Drink plenty of water to replace lost fluids.
If the diarrhoea is severe or continues to be a problem, speak with your pharmacist or doctor for advice Headache Drink plenty of water and ask your pharmacist to recommend a suitable painkiller.Search Menu Abstract Published data have suggested a correlation between antifungal prophylaxis and bacteremia in febrile neutropenia. This correlation was investigated among 3002 febrile neutropenic patients enrolled in 4 trials during 1986-1994.