Active substances: Norfloxacin
Fourteen patients 15 percent failed to show a response to treatment. Of the 48 patients with UTI and defined complications, 36 75 percent had a cure, three 6 percent showed improvement, and therapy failed in nine 19 percent. As such, these drug interactions involving the fluoroquinolones appear to be drug specific rather than a class effect.
The fluoroquinolones have also been shown to interfere with the metabolism of caffeine and the absorption of levothyroxine. This might increase the risk of methotrexate toxic reactions.
Current or past treatment with oral corticosteroids is associated with an increased risk of Achilles tendon rupture, especially in elderly patients who are also taking the fluoroquinolones. Careful monitoring and supportive treatment, monitoring of renal and liver function, and maintaining adequate hydration is recommended by the manufacturer.
At the respective doses, mean peak serum and plasma concentrations of 0. The effective half-life of norfloxacin in serum and plasma is 3—4 hours.
Steady-state concentrations of norfloxacin will be attained within two days of dosing.
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Protect your skin by using a sunscreen, particularly if you are exposed to strong sunlight for a prolonged period of time.
Do not use sunbeds. If you buy any medicines check with a pharmacist that they are safe to take with this antibiotic.
In particular, do not take painkillers called non-steroidal anti-inflammatory drugs NSAIDs, such as ibuprofen, while you are taking norfloxacin.
Some people develop thrush redness and itching in the mouth or vagina after taking a course of antibiotics.
If you think you have thrush, speak with your doctor or pharmacist for advice.Medical uses The initial approval by the U. It licensed use in acute and chronic complicated kidney infections has been withdrawn as a result.