Active substances: Ciprofloxacin
Source control and adequate duration of antibiotic therapy remain essential to prevent recurrence and improve outcomes.
Labelling and quality of antimicrobial products used in chicken flocks in the Mekong Delta of Vietnam. Vet Med Sci, 5 4, pp. Worryingly, 65. Health Technol Assess, 23 38, pp.
The non-inferiority margin was 7. Follow-on PO therapy was permitted in either arm.
An associated cost-effectiveness evaluation assessed health resource use and quality-of-life data. Treatment failure was identified in 141 out of 1015 13.
In the intention-to-treat analysis, using multiple imputation to include all participants, the imputed risk difference between PO and IV therapy for definitive treatment failure was -1.
A complete-case analysis, a per-protocol analysis and sensitivity analyses for missing data each confirmed this result. The population was heterogenous, which facilitated generalisability but limited the statistical power of subgroup analyses.
Participants were only followed up for 1 year so differences in late recurrence cannot be excluded.
These findings challenge the current standard of care and provide an opportunity to realise significant benefits for patients, antimicrobial stewardship and the health economy.
Currently, wide variation in clinical practice suggests significant redundancy that likely contributes to the excess and unnecessary use of antibiotics. Assessing antimicrobial misuse in small-scale chicken farms in Vietnam from an observational study.
BMC Vet Res, 15 1, pp.