Active substances: Ciprofloxacin
+ free Cipro pill.
The mir of the treatment.
Does not cause a …. Take ciprofloxacin exactly as prescribed by your doctor.
Rapid bactericidal activity. A doctor prescribed me the antibiotic medicine Cipro in 500 mg tablets.
Broad spectrum of antimicrobial activity. The number of subjects was determined on the basis of the assumption that quinolone resistance would emerge in the fecal flora in one-third of the volunteers.
Results Subjects Eighty subjects were screened, and 48 28 men and 20 women who fulfilled the predefined criteria for healthy subjects were selected.
The median age was 28. One subject who developed tendinitis at day 8 while receiving 750 mg twice daily and stopped therapy was excluded from the microbiological and pharmacokinetic follow-up analysis.
The remaining 47 subjects had no treatment-related adverse events. In the fecal flora, 1 subject had no detectable E.
All of the strains resistant to ciprofloxacin were also resistant to nalidixic acid. Figure 1 Open in new tab Download slide Number of subjects harboring strains of Escherichia coli in fecal flora that were resistant to nalidixic acid Nal or ciprofloxacin Cip top left or strains of viridans group streptococci in pharyngeal flora that were resistant to levofloxacin bottom left and their corresponding minimum inhibitory concentrations MICs for Nal white circles and Cip black circles top right and levofloxacin bottom right in healthy subjects receiving various regimens of Cip for 14 days.
Strains that were resistant to Cip also appear among strains resistant to Nal. There were 48 subjects at the start of therapy and 47 subjects later, because 1 subject discontinued therapy.
Outcome measures The primary objective of the study was to compare the effect of ciprofloxacin with azithromycin on the time to bacteraemia clearance and fever clearance in individuals diagnosed with typhoid fever.
Time to bacteraemia clearance was defined as time from initiation of antibiotics to time of collection of first persistently negative blood culture for S. Only individuals who were bacteraemic at the time of initiation of antibiotics were included in the analysis of blood culture duration.
Individuals who cleared their fever before antibiotic initiation were excluded from the fever clearance analysis. Typhi stool culture if this occurred after starting antibiotics, and prolonged treatment response defined as persistent S.
Laboratory assays Blood and stool culture samples were collected at 12 hours after challenge and daily thereafter until 96 hours post initiation of treatment. Additional pharmacokinetic studies measurement of ciprofloxacin or azithromycin drug levels in plasma and comparison of liver enzyme derangement were carried out in Study A participants.
Plasma samples from Study A participants were collected at the time of diagnosis prior to commencing antibiotics and 12, 24, 48, 72- and 96-hours post-diagnosis for pharmacokinetic studies.